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The 30 articles summarized in this compendium were identified using the PubMed and Google Scholar databases incorporating the search terms “Delefilcon A Multifocal,” “DAILIES TOTAL1 Multifocal,” “Nelfilcon A Multifocal,” “DAILIES AquaComfort Plus Multifocal,” “Lotrafilcon B Multifocal,” “AIR OPTIX AQUA Multifocal,” and “Precision Profile Design.” Articles were included when they were published between January 1, 2002 and July 31, 2020 and contained research relevant to these three multifocal contact lenses and their indicated use in the United States. Only manuscripts published in peer-reviewed journals and available in English were included in this compendium.